The presence of high levels of cholesterol in the blood is called...


Excess cholesterol in the bloodstream can deposit in the walls of blood vessels leading to a high risk of developing cardiovascular conditions and coronary artery disease, particularly in the arteries that supply blood to the heart (coronary arteries).

  • Cholesterol is a waxy, fat-like substance that is produced in the body and obtained from foods that come from animals (particularly egg yolks, meat, poultry, fish, and dairy products).

  • The body needs cholesterol to build cell membranes, make certain hormones, and produce compounds that aid in fat digestion.

  • Too much cholesterol, however, increases a person's risk of developing heart disease. Hypercholesterolemia is a condition characterized by very high levels of cholesterol in the blood.

The IMPACT Initiative

Cardiovascular disease (CVD) remains the leading cause of death and a major cause of disability in western countries, and it is also becoming increasingly common in developing countries. The causes of CVD are multifactorial; cardiovascular (CV) risk is strongly influenced by lifestyle, especially an unhealthy diet, tobacco use, and sedentary habits, which are modifiable. A relevant role is also played by other modifiable risk factors, such as high blood pressure, diabetes, and dyslipidemias, and by non-modifiable factors like age and male gender.

Control of lipid levels is one of the most effective strategies for CVD prevention. Epidemiologic data have demonstrated the crucial role of dyslipidemia, especially hypercholesterolemia, in the development of CVD. It is well understood that the accumulation of cholesterol-rich low-density lipoprotein (LDL-C) over time leads to formation of lipid-laden foam cells and proliferation of atherosclerotic lesions in arteries, increasing the risk of CVD.

Randomized clinical trials conducted over the past 20 years have consistently demonstrated that the aggressive reduction of LDL-C levels in the blood reduces CV risk in the settings of secondary prevention and high-risk primary prevention.

Our IMPACT program is an online tool that aims to provide clinicians and patients with up-to-date information on the presentation, prognosis, pathophysiology, and treatment strategies for reducing hypercholesterolemia in patients who are at high risk for CVD; the program is designed to help achieve better lipid control and greater improvements in patients’ quality of life. Our goal is to provide information that empowers clinicians and patients to speak openly about treatment decisions and improve the standard of care for patients with hypercholesterolemia.

Thank you for visiting our website. Please explore the Clinician Toolkit and Patient Toolkit links for cutting-edge information on current and emerging treatments for hypercholesterolemia.

Patient & Clinical Toolkits

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